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  • The Mammalian Cell Culture Laboratory (MCCL), headed by Dr. Sonia D. Jacinto, maintains different human cancer cell cultures which are especially used in researches aimed towards discovery of potential anticancer drugs. Focusing on extracts from various Philippine endemic terrestrial plants, the MCCL aims to move the cancer research in the country forward. With the help of various agencies such as the Natural Sciences Research Institute (NSRI), Office of the Vice Chancellor for Research and Development (OVCRD) of UP Diliman and the Department of Science and Technology – Philippine Council for Health Research and Development (DOST-PCHRD), the MCCL is able to support undergraduate and graduate thesis students who work on studies involving cancer. In 2013, with the help of DOST-PCHRD, the MCCL was tasked to establish a National Bioassay Facility that can support studies on drug discovery and development especially on diseases like cancer, diabetes and hypertension among others.

  • Sonia D. Jacinto
    Professor, UP Scientist I
    Head of Laboratory    		 Ahmad Reza Mazahery F. Mazahery, Ph.D.
    Project Leader
    Project Title: Elucidation of the dose-dependent regulatory effects of key TGF-Beta Signalling Molecules on the Proliferaton and Metastatic Behavior of Various Epithelial Cancer Cell Lines
    Maria Bianca Tereza Cruz
    Science Research Specialist
    Project Title: Development of Biorepository Facility for Plant Extracts/Compounds for Drug Discovery    		 Patricia Anne Lim
    Science Research Specialist
    Project Title: Development of Biorepository Facility for Plant Extracts/Compounds for Drug Discovery
    Paul Christian Vicente
    Science Research Specialist
    Project Title: Development of Biorepository Facility for Plant Extracts/Compounds for Drug Discovery    		 Maevel Romero
    Project Development Officer
    Project Title: Development of Biorepository Facility for Plant Extracts/Compounds for Drug Discovery
    Geraldine Quina
    Laboratory Aide
    Project Title: Development of Biorepository Facility for Plant Extracts/Compounds for Drug Discovery    		 Rachelle Anne Dante, M.Sc.
    Science Research Specialist
    Project Title: Screening for Immunomodulatory and Anticancer Activities of Herbal Extracts from Palawan, Samar, Panay, and Sierra Madre
    Katherine Walo
    Laboratory Aide
    Project Title: Screening for Immunomodulatory and Anticancer Activities of Herbal Extracts from Palawan, Samar, Panay, and Sierra Madre    		 Ranelle Janine Asi
    University Research Associate
    Project Title: Elucidation of the dose-dependent regulatory effects of key TGF-Beta Signalling Molecules on the Proliferaton and Metastatic Behavior of Various Epithelial Cancer Cell Lines
    Norielyn Abalos, M.Sc.
    PhD student    		 Regina Joyce Ferrer, M.Sc.
    Instructor
    PhD Student

  • Biosafety cabinet
    Cryogenic storage tank

    Freeze dryer
    HPLC

    Incubator for Cell Culture
    Inverted Fluorescence Microscope

    Multimode reader for reading absorbance, fluorescence and luminescence
    Pharma Ref

    Refrigerated Centrifuge
    Rotary evaporator

    Water Purification System for Ultrapure Water

  • On-Going Research Projects

    1. Development of Biorepository Facility for Plant Extracts/Compounds for Drug Discovery (DOST-PCHRD)

    2. Screening for Immunomodulatory and Anticancer Activities of Herbal Extracts from Palawan, Samar, Panay, and Sierra Madre (DOST-PCHRD)

    • Acebedo AR, Amor E, and Jacinto. 2014. Apoptosis-inducing activity of HPLC fraction from Voacanga globosa (Blanco) Merr. on the human colon carcinoma cell line, HCT116. Asian Pacific Journal of Cancer Prevention 15: 617-622.
    • Dapat E, Jacinto S, Efferth T. 2013. A phenolic ester from Aglaia loheri leaves reveals cytotoxicity towards sensitive and multidrug-resistant cancer cells. BMC Complementary and Alternative Medicine 13:286.
    • Olarte EI, Herrera AA, Vilasenor IM, Jacinto SD. 2013. In vitro antitumor properties of an isolate from leaves of Cassia alata L. Asian Pacific Journal of Cancer Prevention 14: 3191-3196 .
    • Ragasa CY, Torres OB, Shen C-C, Mejia MGR, Ferrer RJ, Jacinto SD. 2012. Chemical constituents of Aglaia loheri. Pharmacognosy Journal 4(32): 29-31.