Alvin R. Acebedo, Ph.D. Assistant Professor 7 Developmental Biology Academic Group Member Ph.D. Medical Science alvinacebedo2015@gmail.com

BIOLOGY 132.1 Animal Developmental Biology (Laboratory)

Mechanisms of the sexually dimorphic morphogenesis of mammalian external genitalia

• Androgen signaling, live imaging microscopy, mutant mouse analyses, mesenchymal condensation, cell migration, cell adhesion, non-muscle myosin

N/A

• Alcantara, M.C., Suzuki, K., Acebedo, AR., Kajioka, D., Hirohata, S., Kaisho, T., Hatano Y., Yamagata, K., Takahashi, S., Yamada, G. (2022). Androgen-regulated MafB drives cell migration via Mmp11-dependent ECM remodeling. iScience. 25 (12).

• Acebedo, AR., Alcantara, MC., Nakanishi, T., Ogawa, T., Yamada, G., Suzuki K. (2022). Exposure to the organophosphate pesticide fenitrothion directly induced defects in mouse embryonic external genitalia. Toxicol Sci. 190 (1), 13-22.

• Alcantara, MC., Suzuki, K., Acebedo, AR., Sakomoto, Y., Nishita, M., Minami, Y., Kikuchi, A., Yamada, G. (2021). Stage-dependent function of Wnt5a during male external genitalia development. Congenit Anom (Kyoto). 61 (6), 212-219.

• Hyuga, T., Suzuki, K., Acebedo, AR., Hashimoto, D., Kajimoto, M., Miyagawa, S., Enmi, JI., Yoshioka, Y. and Yamada, G. (2019). Regulatory roles of epithelial-mesenchymal interaction (EMI) during early and androgen dependent external genitalia development. Differentiation. 110, 29-35.

• Hashimoto, D., Hyuga, T., Acebedo, AR., Alcantara, MC., Suzuki, K. and Yamada, G. (2019). Developmental mutant mouse models for external genitalia formation. Congenit Anom (Kyoto). 59 (3), 74-80.

• Acebedo, AR., Suzuki, K., Hino, S., Alcantara, MC., Sato, Y., Haga, H., Matsumoto, KI., Nakao, M., Shimamura, K., Takeo, T., Nakagata, N., Miyagawa, S., Nishinakamura, R., Adelstein, RS. and Yamada, G. (2019). Mesenchymal actomyosin contractility is required for androgen -driven urethral masculinization in mice. Commun Biol. 2 (95).

• Matsushita, S., Suzuki, K., Murashima, A., Kajioka, D., Acebedo, AR., Miyagawa, S., Haraguchi, R., Ogino, Y. and Yamada, G. (2018). Regulation of masculinization: androgen signalling for external genitalia development. Nat Rev Urol. 15 (6), 358-368.

• Acebedo, AR., Amor, EC. and Jacinto, SD. (2014). Apoptosis-inducing activity of HPLC fraction from Voacanga globosa (Blanco) Merr. on the human colon carcinoma cell. Asian Pac J Cancer Prev. 15 (2), 617-622.

• Verceles, JRF. and Acebedo, AR. (2013). Anti-angiogenic property of Garcinia rubra Merr. Leaf extract as demonstrated in vivo through the chorioallantoic membrane assay. The Philippine BIOTA. 46 (1), 1-15.

• Acebedo, AR. and Jacinto, SD. (2008). Antiangiogenesis Property of Calotropis gigantea Linn. (Dryand) Indicating Anticancer Property. The Philippine BIOTA. 61 (2), 2-11.